Epistasis between the haptoglobin common variant and athalassemia influences risk of severe malaria in Kenyan children
نویسندگان
چکیده
Department of Paediatrics, Oxford University Hospitals National Health Service Trust, University of Oxford, and Oxford University Clinical Academic Graduate School, Oxford, United Kingdom; Kenya Medical Research Institute/Wellcome Trust Research Programme, Centre of Geographic Medicine Research-Coast, Kilifi District Hospital, Kilifi, Kenya; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Wellcome Trust Sanger Institute, Hinxton, United Kingdom; and Department of Medicine, Imperial College, London, United Kingdom
منابع مشابه
Epistasis between the haptoglobin common variant and α+thalassemia influences risk of severe malaria in Kenyan children.
Haptoglobin (Hp) scavenges free hemoglobin following malaria-induced hemolysis. Few studies have investigated the relationship between the common Hp variants and the risk of severe malaria, and their results are inconclusive. We conducted a case-control study of 996 children with severe Plasmodium falciparum malaria and 1220 community controls and genotyped for Hp, hemoglobin (Hb) S heterozygot...
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